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CDC collects, compiles, and analyzes data on influenza activity year round in the United States.

Timing of influenza activity and predominant circulating influenza viruses vary by season. Influenza activity in the United States began to increase in mid-December, remained elevated through February 4, 2016, and is expected to continue for several more weeks.

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Age was reported for 13,306 influenza-positive patients, among whom 1,048 (7.9%) were aged 0–4 years, 4,041 (30.4%) were aged 5–24 years, 4,029 (30.3%) were aged 25–64 years, and 4,188 (31.5%) were aged ≥65 years.

Influenza A (H3N2) viruses predominated in each age group, representing a range of 82.3% of influenza-positives in persons aged 0–4 years to 93.6% in persons aged ≥65 years.

All 66 (100%) influenza B/Yamagata-lineage viruses were antigenically similar to B/Phuket/3073/2013, the recommended influenza B component of the 2016–17 Northern Hemisphere quadrivalent vaccine.

The WHO Collaborating Center for Surveillance, Epidemiology, and Control of Influenza at CDC tested 807 influenza virus specimens (94 influenza A (H1N1)pdm09, 519 influenza A (H3N2), and 194 influenza B viruses) collected in the United States from October 1, 2016, through February 4, 2017, for resistance to the influenza neuraminidase inhibitor antiviral medications oseltamivir, zanamivir, and peramivir, drugs currently approved for use against seasonal influenza.

Influenza A (H3N2) virus HA gene segments analyzed belonged to genetic groups 3C.2a (567 viruses) or 3C.3a (26 viruses).

Genetic group 3C.2a includes an emerging subgroup defined as 3C.2a1.Early treatment with neuraminidase inhibitor antiviral medications is recommended for patients with severe, complicated, or progressive influenza illness and those at higher risk for influenza complications, including adults aged ≥65 years. Influenza activity in the United States began to increase in mid-December, remained elevated through February 4, 2017, and is expected to continue for several more weeks. World Health Organization (WHO) and National Respiratory and Enteric Virus Surveillance System laboratories, which include both public health and clinical laboratories throughout the United States, contribute to virologic surveillance for influenza.To date, influenza A (H3N2) viruses have predominated overall, but influenza A (H1N1)pdm09 and influenza B viruses have also been identified. During October 2, 2016–February 4, 2017, clinical laboratories in the United States tested 392,901 respiratory specimens for influenza viruses, 38,244 (9.7%) of which were positive (Figure 1).Among 267 influenza A (H3N2) viruses, 258 (96.6%) were antigenically similar to the A/Hong Kong/4801/2014–like cell propagated reference virus belonging to genetic group 3C.2a, which is the recommended influenza A (H3N2) component of the 2016–17 Northern Hemisphere vaccine.Seventy (90.9%) of 77 influenza B/Victoria-lineage viruses were antigenically similar to B/Brisbane/60/2008, which is the recommended influenza B component of the 2016–17 Northern Hemisphere trivalent and quadrivalent vaccines.What are the implications for public health practice?

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